Cyclotron Road Founding Director Ilan Gur delivered an inspirational keynote address on February 27th, 2017 at the annual ARPA-E Summit. Entitled “A new pathway for science innovation” the talk describes the gaps in our research ecosystem that prevent entrepreneurial scientists and engineers from bringing new technologies to market. After a discussion of the historical backdrop that created this situation Ilan suggests some approaches to bridging these gaps moving forward.